Feb 6, 2020 · This review addresses early risk features associated with asymptomatic severe AS in an attempt to help inform management. The following are key points to remember: Echocardiography/Doppler continue to provide important data …

Sep 14, 2022 · In general, symptoms in patients with AS and normal LV systolic function rarely occur until the stenosis is severe, as defined by an antegrade maximum aortic velocity over 4.0 m/s and/or mean transvalvular gradient exceeding 40 mmHg.

Feb 4, 2015 · Asymptomatic patients are classified as Stage A disease if they are at risk of developing AS but currently have normal leaflet opening without valve obstruction, for example, a young patient with a normally functioning bicuspid valve or …

Nov 16, 2019 · We conducted this multicenter, randomized, parallel-group, open-label trial involving asymptomatic patients with very severe aortic stenosis who were candidates for either early surgery or...

New insights into the natural history and pathophysiology of patients with aortic stenosis (AS), coupled with the dramatic evolution of transcatheter aortic valve implantation (TAVI), are fuelling intense interest in the management of asymptomatic patients with severe AS.

Asymptomatic patients with severe aortic stenosis are first screened for left ventricular decompensation by using high-sensitivity troponin I (hs-TnI) and electrocardiogram (ECG). A total of 1,000 patients at higher risk for left ventricular decompensation (e.g., troponin levels >6.0 ng/l) then proceed to magnetic resonance imaging.

May 1, 2024 · In this review, we highlight advances in the management and risk stratification of patients with asymptomatic severe aortic stenosis with particular consideration of recent findings supporting early valvular intervention.

Oct 28, 2024 · At 75 centers in the United States and Canada, we randomly assigned, in a 1:1 ratio, patients with asymptomatic severe aortic stenosis to undergo early TAVR with transfemoral placement of a...

Sep 14, 2022 · (See "Clinical manifestations and diagnosis of aortic stenosis in adults", section on 'Complications'.) The only effective treatment for symptomatic severe AS is valve replacement (surgical AVR [SAVR] or transcatheter aortic valve implantation [TAVI]).

May 20, 2020 · An interventional approach in patients with asymptomatic aortic stenosis (AS) includes two possible procedures: surgical aortic valve replacement (SAVR), and transcatheter aortic valve replacement (TAVR).