A spleen volume reduction of 10% or more showed the greatest separation in overall survival curves between patients treated with pacritinib who had a spleen volume reduction and those who did not.

JAK inhibitors are usually associated with reduced spleen size and improved symptoms but durability of response and the development of resistance to treatment continues to be a problem. The strengths ...

The limited number of studies available and the low quality of scientific evidence hamper a detailed understanding of PNH in the Latin American region. A new narrative review of characteristics and ...

The levels of circulating HMGB1 and S100A8/A9 were increased in patients with MF and this increase correlated with the degree of systemic inflammation. Damage-associated molecular patterns (DAMPs) ...

Researchers analyzed electronic health record data for patients in the US with MG between January 2013 and December 2022. Glucocorticoid Toxicity Index-Metabolic Domains scores were higher in the ...

The rats that received the CLC-1 inhibitor exhibited improved neuromuscular transmission by stimulated EMG as well as muscular and pulmonary function. Skeletal muscle-specific chloride ion channel ...

Which of the statements below about the therapeutic study on Centella asiatica in transthyretin amyloid polyneuropathy (ATTR-PN) are correct? Select one of the options for each question, then submit ...

Marstacimab-hncq is a once-weekly, subcutaneous treatment that aims to reduce bleeding episodes, providing an alternative to frequent intravenous infusions. The US Food and Drug Administration (FDA) ...

During treatment with nusinersen there was a mean reduction in performance fatigability of 5.6%. Performance fatigability is an independent component of motor impairment and, therefore, a potential ...

Being a primary biliary cholangitis (PBC) advocate is a hard job. It comes with a lot of interpersonal battles as well as challenges I never expected to encounter. Although my advocacy journey feels ...

The New York Heart Association class improved or remained stable for 77.6% of patients treated with tafamidis as part of an early access program.

The toxic effect of the TTR amyloid aggregates was reduced in a dose-dependent manner with C. asiatica extract treatment. To explore whether the hydrophilic extract of C. asiatica could suppress the ...