Eight months later, the pain of losing a second Super Bowl in five seasons to the Kansas City Chiefs has barely subsided for the San Francisco 49ers as they prepare for a rare regular season rematch.

San Francisco 49ers head coach Kyle Shanahan, wide receiver Deebo Samuel Sr. and defensive lineman Nick Bosa discuss gameplanning for the team's fifth meeting with the Kansas City Chiefs since 2018.

The San Francisco Giants have multiple ways to improve this offseason, but there's a need for another middle-infielder. If ...

The San Francisco 49ers got mixed injury news overall to start their week of practice ahead of a Week 7 showdown with the ...

Defense attorneys for Bob Lee’s accused killer, Nima Momeni, admitted in opening statements that Momeni stabbed the tech ...

The justices heard arguments on Wednesday in a long-simmering dispute between San Francisco and the E.P.A. over regulation of ...

Five airlines are poised to win permission for new new long-haul flights to Ronald Reagan Washington National Airport.

Preview the Week 8 college football San Diego Toreros vs. Marist Red Foxes game with stats, game information and how to watch ...

Preview the Week 8 college football San Jose State Spartans vs. Wyoming Cowboys game with stats, game information and how to ...

From the ‘Godfather of AI’ to the discoverer of microRNA, the four new Nobelists have made remarkable advances in medicine, ...

Sheryl Davis, who resigned last month as head of San Francisco’s landmark Dream Keeper Initiative amid reports of misspending ...

At around 4 a.m. on Tuesday, police officers assigned to Mission Station responded to a shooting on Mission Street between ...