Joint injury induces rapid and sustained diversification of resident and infiltrating synovial macrophage phenotypes, underpinning osteoarthritis-associated synovitis.

Anti-CD20 mAbs were originally created to treat B cell proliferative diseases such as non-Hodgkin's lymphoma and chronic ...

In monocytes and other immune cells ... that investigating the metabolic profile of immune cells can allow inferences to be made about their differentiation state. In this study, chronological ...

Treatment of monocytes and macrophages with high concentrations ... in which the initial gene targeting was undertaken. ES-cell differentiation. Before differentiation, ES cells were trypsinized ...

Monocytes were plated in 12-well plates at 300,000 cells per well and incubated in macrophage differentiation media (RPMI 1640 containing 10% FBS, 100 units/mL penicillin, 100 μg/mL streptomycin, 250 ...

In diabetes mellitus, the proliferation of resident macrophages in bone microenvironment is limited, while enhanced myeloid differentiation of hematopoietic stem cells (HSCs) leads to increased and ...

In this study, we investigated the cellular source of GM-CSF in RA-SF and the contribution of RA-SF T-cell-derived GM-CSF in infDC differentiation from PB monocytes. Our data demonstrate that CD4+ T ...

In contrast, genes associated with regulation of OC differentiation, iron metabolism and regulation of pH were enriched in non-classical monocytes (figure 5D). Elucidating the mechanisms leading to ...

Monocytes are considered to be recruited to the intestine ... This promotes M2 macrophage differentiation, creating a positive feedback loop to recruit immunosuppressive cells and generate a ...

The manuscript addresses the 3D chromatin architecture in monocytes from patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the ...

Atherosclerosis cardiovascular disease (ASCVD)-related mortality is higher in patients with lupus nephritis (LN) compared ...