eLife1d
Genome Restructuring around Innate Immune Genes in Monocytes in Alcohol-associated Hepatitis
The manuscript addresses the 3D chromatin architecture in monocytes from patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the ...
Study reveals immune system's crucial role in amyotrophic lateral sclerosis at cellular level
A team of researchers from the Sant Pau Research Institute (IR Sant Pau) has published a study in the Journal of ...
eLife4d
Identification of a sub-population of synovial mesenchymal stem cells with enhanced treatment efficacy in a rat model of Osteoarthritis
This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...
ahajournals.org4d
Lipoprotein(a) as a Pharmacological Target: Premises, Promises, and Prospects
Atherosclerotic cardiovascular disease is a major health concern worldwide and requires effective preventive measures. Lp(a) (lipoprotein [a]) has recently garnered attention as an independent risk ...
gut.bmj6d
Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
It was recently shown that monocyte/macrophage infiltration into the liver upon injury is critically regulated by the CCL2/CCR2 axis and is functionally important for perpetuating hepatic inflammation ...
Scientific Research Publishing5d
Lee, K.Y. (2019) M1 and M2 Polarization of Macrophages: A Mini-Review. Medical Biological Science and Engineering, 2, 1-5.
Some natural immunity elements play a role in the development of pulmonary fibrosis, and macrophages are among them. At first, they prevent lung injury by encouraging inflammation and attracting ...