An increased reliance on purine nucleotide metabolism (via myoadenylate deaminase) and phosphocreatine hydrolysis to generate ATP produces ... β-Oxidation of acyl-CoA to acetyl-CoA then occurs at the ...
Related experimental studies have also shown that CGA can decrease the excess fat deposition by reducing the mRNA expression of FAS, acetyl-CoA carboxylase ... thereby delaying hydrolysis. In summary, ...
75 Sildenafil and tadalafil are reversible competitive inhibitors of the catalytic domain of PDE-5 involved in the hydrolysis of cGMP ... enables the irreversible oxidation of pyruvate to acetyl-CoA, ...
Fibroblast growth factors (FGFs) signal through FGF receptor tyrosine kinases to regulate a wide range of biological processes during development and adulthood. FGF receptors (FGFRs) are involved ...
SLC25A1 drives citrate export from the mitochondria to the cytosol, where it fuels acetyl-CoA synthesis by ATP citrate lyase (ACLY). This acetyl-CoA supply sustains FSP1 acetylation and prevents its ...
decreasing lipogenesis by decreasing the enzymatic conversion of acetyl CoA to FAs; increasing ß-oxidation of FA; inhibiting both PAP (an enzyme that catalyzes that reaction of converting PA to ...
Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 301700, ...
However, existing supersulfide donors are limited to releasing RSSH. Compared to RSSH, hydrotrisulfide (RSSSH) is a more mysterious molecule that harbors an additional zerovalent sulfur atom, which is ...
As the most metabolically demanding organ in the body, the heart must generate massive amounts of energy adenosine triphosphate (ATP) from the oxidation of fatty acids, carbohydrates and other fuels ...
aCentre for Rheumatology Research, Department of Medicine, University College London, Rayne Building, London W1CE 6JF, UK bCentre for Adolescent Rheumatology Versus Arthritis, Department of Medicine, ...
Migratory locusts display striking phenotypical plasticity. Gregarious locusts at high density can migrate long distances and cause huge economic losses of crops. By contrast, solitary locusts at low ...
In this important work, Lodhiya et al. provide evidence that excessive ATP underlies the killing of the model organism Mycobacterium smegmatis by two mechanistically-distinct antibiotics. The data are ...
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