Multiple user reports have popped up of NVIDIA's RTX 5090 cards (from the few users who have managed to buy one, at least) ...
Adding over temperature and over current protections to each 12V-2x6 wire should detect any anomalies and cut the power ...
The Nvidia gaming GPUs will instead use an eight-pin connector and will also only need a 650W power supply, if this latest rumor is true.