BioSpace15d
Zentalis Pharmaceuticals Shares Updated Clinical Data Demonstrating Meaningful Azenosertib Activity in Cyclin E1+, Platinum-Resistant Ovarian Cancer
“We are excited to outline a clear path for Zentalis to bring azenosertib to patients with Cyclin E1+ PROC,” said Ingmar Bruns, M.D., Chief Medical Officer. “In a patient population with a clear unmet ...
The EMBO Journal16d
Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21-P27KIP1-mTOR axis
Specifically, hSPAR fulfills its functions by two coordinate pathways: On one hand, hSPAR stabilizes the protein level of P27KIP1 in the cytoplasm by blocking TRIM21-mediated ubiquitin-proteasome ...
Medscape25d
Impact of EBV Essential Nuclear Protein EBNA-3C on B-cell Proliferation and Apoptosis
In addition, EBNA-3C enhances E2F1 degradation by recruiting ubiquitin–proteasome machinery [97] Cyclin E In vitro using GST-fused protein incubated with radiolabeled EBNA-3C No direct ...
Frontiers26d
Research progress on Sertoli cell secretion during spermatogenesis
Sichuan Provincial Key Laboratory of Traditional Chinese Medicine Regulation of Metabolic Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China Sertoli ...