To flesh out the mechanism, the researchers knocked out genes one by one with CRISPR. They found that cells missing FBXO31, a substrate adaptor for the SCF ubiquitin ligase complex, were unable to ...

Ubiquitin is an intracellular signalling molecule that is conjugated to various proteins. Ubiquitin conjugation to itself yields Lys- or Met-conjugated chains, thus expanding its repertoire of ...

The SCF (SKP1/CUL1/F-box protein) ubiquitin ligase complex plays a protective role against external stress, such as ultraviolet irradiation. The emergence of substrates activates SCF through ...

In addition, EBNA-3C enhances E2F1 degradation by recruiting ubiquitin–proteasome machinery [97] Cyclin E In vitro using GST-fused protein incubated with radiolabeled EBNA-3C No direct ...

Additionally, the identification of cyclin E overexpression as a key driver of resistance offers a target that will be of value for future therapeutic strategies, potentially improving outcomes for ...

Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark Department for Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark Department of ...

The ubiquitin-proteasome system (UPS ... p-Rb at Ser780) were overexpressed, while cyclin-dependent kinase 4 (CDK4) and p-p53 at Ser392 were downregulated (Yin et al., 2012). The accumulation of P53 ...

“We are excited to outline a clear path for Zentalis to bring azenosertib to patients with Cyclin E1+ PROC,” said Ingmar Bruns, M.D., Chief Medical Officer. “In a patient population with a clear unmet ...

Ubiquitination is a PTM characterized by the covalent binding of ubiquitin (Ub) molecule to a specific target protein. This essential PTM primarily determines protein stability by marking the target ...

Bcl-3, together with the NF-кB family member p50/p52, is recruited to the cyclin D1 promoter and initiates cyclin D1 transcription [19,20]. The recruitment of Bcl-3 to the cyclin D1 in keratinocytes ...