This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...

Rheumatoid arthritis (RA) is an autoimmune disorder affecting millions worldwide, causing chronic inflammation, debilitating pain, and irreversible joint damage.

Rheumatoid arthritis (RA) is a complex condition that is well characterised by chronic inflammation in the synovial membrane of affected joints, often with systemic manifestations. Yet the aetiology ...

Macrophages are the most abundant immune cells in the synovial membrane of OA and are involved in both maintaining and resolving the inflammatory process. Moreover, inflammatory infiltrates coexist ...

They can be found in both layers of this synovial membrane and contribute to normal joint function by producing extracellular matrix components and lubricants. However, under inflammatory conditions ...

hyperplasia of the synovial membrane is a hallmark of RA pathology, which is characterized by both hyperproliferation of synovial fibroblasts and massive infiltration of inflammatory immune cells, ...

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Joint injury induces rapid and sustained diversification of resident and infiltrating synovial macrophage phenotypes, underpinning osteoarthritis-associated synovitis.

RANKL is expressed on T cells and fibroblasts within the synovial inflammatory tissue of patients with RA and its expression is regulated by proinflammatory cytokines. In animal models of ...

Nearly every disease has an inflammatory component, but blood tests can't pinpoint inflammation in specific organs or tissues in the human body. Now researchers have developed a method to detect ...