Furthermore, changes in efficacy at excitatory synapses are thought to underlie ... during LTD. By analogy with LTP, a very simple model would predict that, following removal or endocytosis ...

The SYNGAP1 gene, which supports the production of a protein called SynGAP (Synaptic Ras GTPase-Activating Protein), is known ...

However, the study provides limited new insights into the relationship between retinal lamination defects and overall retinal function. Neural lamination is a common feature of the central nervous ...

Enter SynPull, a new synaptosome imaging method developed by David Klenerman, John Danial, and colleagues at the University of Cambridge, England. SynPull combines single-molecule pull-down of ...

Hence, researchers often simulate the brain as a network of coupled neural masses, each described by a mean-field model. These models capture the essential features of neuronal populations while ...

A 3D model accurately mimicking the blood-brain barrier (BBB) in a laboratory environment has been successfully developed by ...

[Originally published in Synapse on February 10, 2009.] Last month we honored the birth of civil rights leader Dr. Martin... Snow is falling today and I hugged goodbye to my best friend at the Z.

When OpenAI announced a new generative artificial-intelligence (AI) model, called o3, a few days before Christmas, it aroused both excitement and scepticism. Excitement from those who expected its ...

We here review the unique knowledge on actin dynamics at the T lymphocyte synapse gained through the study of primary immunodeficiences caused by mutations in genes encoding actin regulatory proteins.

There, they begin to form connections with other neurons. The process of forming these connections, or synapses, is called synaptogenesis. It occurs rapidly in the months before and after birth ...