When activated by semaphorin-3A (SEM3A), which is upregulated in MS lesions, the heterodimer inhibits two critical steps of remyelination: the differentiation of oligodendrocyte progenitor cells ...

Multiple sclerosis (MS) is an autoimmune disease ... Electron micrographs of the lumbar spinal cord showed remyelination in EAE-induced, Lingo1-knockout mice, but demyelination in wild-type ...

Moreover, the discovery of several compounds that can promote remyelination in animal models offers hope that function can be ...

MS was long considered a T-cell mediated disorder ... coupled with failed compensatory mechanisms like neuroplasticity and ...

A recent drug discovery could eventually help the visually impaired and those suffering from multiple sclerosis, traumatic stroke, and Alzheimer’s disease regain some of their vision and mental ...