Biology lectures teach students that when a cell’s replication machinery comes together, DNA polymerase takes off down the double-helix like a car on a highway ...

The high accuracy or fidelity of semi-conservative DNA replication is the product of nucleotide template interaction, polymerase-enhanced base selectivity, exonuclease proofreading and the post ...

A retrovirus with an RNA genome, which is copied into DNA by a reverse transcriptase, is prone to mutations because the enzyme lacks the 3’ to 5’ proofreading capability ... then amplifying the DNA ...

which is the replicative DNA polymerase in the replisome, (prepared from a strain deleted of the genes for all the TLS polymerases and with the proofreading exonuclease fully active) itself could ...

You have full access to this article via your institution. Figure 1: Reduced survival and increased tumor incidence in Pold1 D400A/D400A mice.