However, the specific mechanisms by which DHIE regulates p53 in different subtypes of breast cancer and ... PLK4, and TYMS from the PDB database, and modified the protein by deleting ligands and water ...
which bind to the proteins target RELA (PDB ID: 6NV2) and p53 (PDB ID: 2OCJ). The Hexa, Fluo and Octa compounds' tests were negative for AMES toxicity, indicating that these compounds do not cause ...
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Background: Over-proliferation of mesangial cells (MCs) is one of the main pathological changes in the early stages of diabetic kidney disease (DKD). Roxadustat, an oral hypoxia-inducible factor (HIF) ...
Department of Food Chemistry and Biotechnology, Faculty of Chemistry, Brno University of Technology, Purkyňova 118, Brno 612 00, Czech Republic ...
Protein Data Bank (PDB) files are 3D molecular files that store molecular structures. Now, if you are wondering how to open such files on a PC, this post will interest you. Here, we will discuss ...
DNA double-strand breaks (DSBs) can lead to mutations, chromosomal rearrangements, genome instability, and cancer. Central to the sensing of DSBs is the ATM (Ataxia-telangiectasia mutated) kinase, ...
Inflammation is an essential aspect of innate immunity but also contributes to diverse human diseases. Although much is known about the kinases that control inflammatory signaling, less is known about ...
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