upregulating p53 and downregulating the expression of proteins such as FAK, Hsp90, LYVE-1, and VEGF-C(Its specific mechanism of suppressing metastasis and invasion is shown in Figure 3). Figure 3.

5Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, ...

Clinical Physiology provides diagnostic methods to detect and evaluate dysfunction of various organs and systems in the body such as the heart, peripheral vessels, lungs, kidneys, gastrointestinal ...

Among them, heat-shock protein 90 (Hsp90) stands out as an essential proteostasis hub in eukaryotes, chaperoning hundreds of ‘clients’ (substrates). After decades of research, several ‘known unknowns’ ...

According to the World Health Organization, cancer is one of the leading global health concerns, causing nearly 10 million deaths in 2020. While classical chemotherapeutics produce strong cytotoxicity ...

Cells depleted of MCMBP gradually ceased to proliferate because of reduced replication licensing. Under this condition, p53-positive cells exhibited arrest in the G1 phase, whereas p53-null cells ...

Heat-shock protein 90 (Hsp90) inhibitor downregulates c-Myc expression and upregulates the expression of tumor repressor proteins such as p53 and pRB, inhibiting the G1/S transition and causing G2 ...