Researchers discover that bone marrow cancer cells diversify drastically when exiting the bone marrow, which also affects the ...

The team tackled a critical challenge in treating multiple myeloma—a blood cancer where malignant plasma cells accumulate in bone marrow, leading to debilitating bone lesions in 80% of patients.

When blood cancer cells break through the bone and multiply, tumor cells become dangerously diverse and the immune response in the region changes, researchers report. The detailed insights into cancer ...

A research team from the Heidelberg Medical Faculty, the German Cancer Research Center (DKFZ), the Berlin Institute of Health ...

Throughout my experience with multiple myeloma, I was humbled by the unexpected support and kindness shown to me.

Bone disease is a hallmark of multiple myeloma (MM), associated with bone ... It correlates with quality of life and survival. Osteolytic bone lesions are the result of excessive bone resorption ...

During a Case-Based Roundtable® event, Muhammad Umair Mushtaq, MD, discussed managing long-term toxicity concerns related to ...

Early treatment with intravenous bisphosphonates at first radiographic evidence of bone lesions in patients with solid tumors or evidence of osteopenia in patients with multiple myeloma can ...

More information: Raphael Lutz et al, Bone marrow breakout lesions act as key sites for tumor-immune cell diversification in multiple myeloma, Science Immunology (2025). DOI: 10.1126/sciimmunol ...