Figure 5. Schematic diagram of critical proteins required for the replication and transcription of mtDNA. TWINKLE is an mtDNA helicase that catalyzes the unwinding of duplex DNA using energy from NTP ...
Apoptosis occurs in a wide range of human diseases. In animal models of virus-induced disease, apoptosis correlates with viral titre and can be found in areas targeted by viral infection, which ...
As discussed above, the mitochondrial proteome is encoded by both mitochondrial and nuclear DNA. Proteostatic stress can arise ... are then delivered to lysosomes for degradation. Figure 5. Schematic ...
Mitochondrial DNA (mtDNA) is actively removed during spermatogenesis in a conserved process that enforces the uniparental ...
Exonuclease action of replicative polymerase gamma drives damage-induced mitochondrial DNA clearance
How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA clearance following damage, driven by the exonuclease activity of the mtDNA ...
This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...
The manuscript addresses the 3D chromatin architecture in monocytes from patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the ...
ZME Science on MSN5d
This massive circular structure is made entirely of mammoth bones and skulls. DNA now offers clues about how Ice Age hunters built itThe Kostenki 11 site, located near the Don River, just 300 kilometers from Moscow, is one of the most significant Upper ...
While a variety of genetic data is already used by cattle breeders, information from the mitochondrial genome of an animal has been largely ignored, notes the release. This federally funded study will ...
This was associated with enhanced production of oxidised mitochondrial (oxmt)DNA. OxmtDNA induced ISG expression in healthy PBMC, which was blocked by targeting oxidative stress and intracellular ...
The difficulties arise when no known mtDNA defect can be found, or when the clinical abnormalities are complex and not easily matched to those of the more common mitochondrial disorders. We will ...
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