To investigate the role of epigenetic histone modifications on uric acid-induced priming that results in aggravated IL-1β, histone methyltransferase inhibitor, MTA (5′-deoxy-5′-methylthio-adenosine), ...

Because the p53 pathway is inactivated by deletion of mutation of p53 or by inhibitor overexpression (e.g., Mdm2 or Mdm4 overactivation), reactivating the WT p53 must be specifically designed to the ...