People with Stargardt disease have too much lipofuscin -- it builds up over the macula, which is the central part of the retina and is responsible for clear and sharp central vision. Stargardt ...

The disease is characterized by changes in the retinal pigment epithelium (RPE ... of harmful substances in the RPE, such as lipofuscin and drusen deposits, which are associated with the ...

GA areas exhibit very low to extinguished autofluorescence signal as RPE and photoreceptor cell death is accompanied by loss of lipofuscin.10 20–22 The latter aspect leads to a high contrast between ...

Stargardt macular dystrophy (Stargardt disease; STGD1; OMIM 248200) is the most prevalent inherited macular dystrophy. STGD1 is an autosomal recessive disorder caused by multiple pathogenic sequence ...

In addition, ocular gene therapy for inherited retinal degeneration is showing benefit in early clinical trials. [1–3] Stimuli-responsive NPs may also act as biosensors in the intraocular milieu.

In their last study, IIT's research group saw for the first time that Ziapin2 also acts in a similar manner on neurons in the inner retina unaffected by degeneration, particularly at the bipolar ...

Retinal ganglion cells (RGCs) are the bridging neurons that connect the retinal input to the visual processing centres within the central nervous system. There is a remarkable diversity of RGCs and ...

Toward that goal, the application of adaptive optics (AO) and full-field scanning to a variety of eye imaging techniques has further allowed the histologic study of single cells in the retina and ...

A corneal abrasion is a scratch on your eye. It can happen in an instant — such as when you poke your eye or something (like dirt or sand) gets trapped under your eyelid. Your eye hurts, and ...

Meanwhile, blue light causes photochemical damage to the retina, and may be associated with age-related macular degeneration (AMD). At present, clear intraocular lenses (IOLs) and blue-blocking IOLs ...

When it comes to addressing uneven skin texture and tone, laxity and general glow – and creating beautiful skin – retinol is the gold standard. In fact, the best retinol serums and creams can be a ...