pORF36 phosphorylates Thr111 of KSHV basic region-leucine zipper (K-bZIP) and inhibits the SUMO level of K-bZIP to repress the transcriptional inhibition activity. pUL13 acts as a serine/threonine ...

If it can inhibit the activity of glycolysis-related enzymes and control the energy metabolism of tumor, it can be targeted for the treatment of malignant tumor. The target proteins phosphoglycerate ...

In cancers, all translocations involving ALK produce fusion proteins with constitutive tyrosine kinase activity that in most cases derives from spontaneous dimerization induced by the different ...

LRRK2 has two enzyme "domains"—a kinase and GTPase domain ... to make the inhibitor more targeted to regulate just the activity of LRRK2.

In 2020-2021, a mysterious skin disease affected fishermen in Senegal. High levels of Portimine A toxin, produced by the ...

This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...

LRRK2 has two enzyme "domains"—a kinase and GTPase domain ... to make the inhibitor more targeted to regulate just the activity of LRRK2. "The inhibitor we identified previously targets LRRK2 ...

Excalidraw is an innovative online whiteboarding tool that uses the power of artificial intelligence (AI) to convert simple text prompts into detailed, professional-quality diagrams. Whether you ...

Laboratory for Research on the Structure of Matter (LRSM), University of Pennsylvania, Philadelphia, United States ...

Seven adventure training centres have closed after the firm that ran them went into administration Seven residential activity centres for schools have closed after the company that ran them went ...