C&EN8d
If insulin can’t get into tissues, it can’t act
If insulin can’t get out of blood vessels, it can’t act in its target tissues. “Endothelial cells are full of insulin ...
Medscape5d
Are Oxidative Stress-Activated Signaling Pathways Mediators of Insulin Resistance and Beta-Cell Dysfunction?
In addition, there is evidence that in type 2 diabetes, the activation of these same pathways by elevations in glucose and free fatty acid (FFA) levels leads to both insulin resistance and ...
News Medical on MSN12d
A pathway that contributes to insulin resistance can be targeted, mouse study shows
The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...
GEN11d
Obesity-Linked Hormone Adrenomedullin Disrupts Insulin Signaling
Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type ...
BioWorld6d
Adrenomedullin pathway leads to insulin resistance in obesity
Adrenomedullin, a hormone first identified in an adrenal medullary tumor, disrupts the effect of insulin on the endothelium of blood vessels, leading to insulin resistance linked to obesity and type 2 ...