Treatment for chronic pain still relies heavily on opioids. While effective, they are highly addictive and potentially deadly ...

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Janahi and colleagues [14] reported the successful use of nebulized morphine sulfate 2 mg, dexa-methasone 2.5 mg, and 0.9% sodium chloride injection 2.5 mL administered every four hours as needed ...

1 As current standard-of-care options for triple-negative breast cancer are focused on chemotherapy and immunotherapy, exploring androgen receptor (AR)-targeted therapy offers new avenues for patients ...

Summary: New research sheds light on how ketamine affects the brain by targeting a specific NMDA receptor subtype, GluN1-2B-2D. Scientists used electron cryo-microscopy to capture how ketamine binds ...

1 Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montréal, Quebec, Canada Background Androgens have been shown to influence both the immune system and lung tissue, ...

Université de Bordeaux, INCIA, UMR 5287, 33076, Bordeaux, France CNRS, INCIA, UMR 5287, 33076, Bordeaux, France Université de Bordeaux, IMN, UMR 5293, 33076 ...

Androgen and androgen deprivation (castration) therapies, including androgen receptor antagonists, are clinically used to treat patients with prostate cancer. However, most hormone-dependent prostate ...

In patients with castration-resistant prostate cancer (CRPC), clinical resistances such as androgen receptor (AR) mutation, AR overexpression, and AR splice variants (ARVs) limit the effectiveness of ...

Breast cancer (BC) is one of the most common malignancies and the leading cause of cancer-related mortality in women. Androgen receptor (AR) is frequently expressed in diverse BC subtypes.