Scientists propose CDK2 enzyme as new target for cancer therapy
An enzyme called cyclin-dependent kinase 2 (CDK2) regulates the cell cycle and may have the potential to drive therapeutic ...
eLife18d
Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer
Additionally, the identification of cyclin E overexpression as a key driver of resistance offers a target that will be of value for future therapeutic strategies, potentially improving outcomes for ...
Cancer Research24d
Triple Combination of MEK, BET, and CDK Inhibitors Significantly Reduces Human Malignant Peripheral Nerve Sheath Tumors in Mouse Models
1Hereditary Cancer Program, Catalan Institute of Oncology (ICO-IDIBELL), Hospitalet de Llobregat, Barcelona, Spain. 2Program in Molecular Mechanisms and Experimental Therapy in Oncology (Oncobell), ...
The EMBO Journal1mon
Gut microbiota interact with breast cancer therapeutics to modulate efficacy
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The gut microbiome, or the community of ...
C&EN1mon
pH-Dependent Electrocatalytic Aqueous Ammonia Oxidation to Nitrite and Nitrate by a Copper(II) Complex with an Oxidation-Resistant Ligand
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520, United States Energy Sciences Institute, Yale University, 810 West Campus Drive, West Haven, Connecticut ...
GitHub2y
Landing Zone Accelerator on AWS
These complementary capabilities provides a comprehensive low-code solution across 35+ AWS services to manage and govern a multi-account environment built to support customers with highly-regulated ...