“We are excited to outline a clear path for Zentalis to bring azenosertib to patients with Cyclin E1+ PROC,” said Ingmar Bruns, M.D., Chief Medical Officer. “In a patient population with a clear unmet ...

Specifically, hSPAR fulfills its functions by two coordinate pathways: On one hand, hSPAR stabilizes the protein level of P27KIP1 in the cytoplasm by blocking TRIM21-mediated ubiquitin-proteasome ...

In addition, EBNA-3C enhances E2F1 degradation by recruiting ubiquitin–proteasome machinery [97] Cyclin E In vitro using GST-fused protein incubated with radiolabeled EBNA-3C No direct ...

Sichuan Provincial Key Laboratory of Traditional Chinese Medicine Regulation of Metabolic Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China Sertoli ...

Phosphorylation regulates p27 binding to and inhibition of cyclin–Cdk complexes, its localization and its ubiquitin-mediated proteolysis. In cancers, p27 is inactivated through impaired ...

CHIP mutation prompts the upregulation of cAMP, increasing PKAc and further competitively inhibiting the ubiquitin-mediated degradation of PDE9A. Pharmacological inhibition of PDE9A- or AAV-mediated ...

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences & IOCB Research Centre, Flemingovo nám. 2, 166 10 Prague, Czech Republic Institute of Organic ...

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Welcome to the TFG Supply Chain Finance (SCF) and Payables Finance hub. Find out about how we help corporates and large businesses access supply chain finance programmes, or keep up to date with the ...

What should I know about this firm? Scf Investment Advisors Inc is a national financial advisory firm headquartered in San Diego, CA. The firm has $2.6 billion under management and employs 62.The ...