To flesh out the mechanism, the researchers knocked out genes one by one with CRISPR. They found that cells missing FBXO31, a substrate adaptor for the SCF ubiquitin ligase complex, were unable to ...

The SCF (SKP1/CUL1/F-box protein) ubiquitin ligase complex plays a protective role against external stress, such as ultraviolet irradiation. The emergence of substrates activates SCF through ...

Ubiquitin is an intracellular signalling molecule that is conjugated to various proteins. Ubiquitin conjugation to itself yields Lys- or Met-conjugated chains, thus expanding its repertoire of ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

In addition, EBNA-3C enhances E2F1 degradation by recruiting ubiquitin–proteasome machinery [97] Cyclin E In vitro using GST-fused protein incubated with radiolabeled EBNA-3C No direct ...

Jalen Hurts has a magical time celebrating the Super Bowl win at Disney World Amy Schumer is dishing to E! News about her new Netflix comedy 'Kinda Pregnant' and jokingly reveals which A-list ...

Wicked’s Cynthia Erivo detailed the special moment she shared with Taylor Swift at the 2025 Grammys in an exclusive interview with E! News at the Critics Choice Awards Feb. 7. Adam Brody and ...

Additionally, the identification of cyclin E overexpression as a key driver of resistance offers a target that will be of value for future therapeutic strategies, potentially improving outcomes for ...

The ubiquitin-proteasome system (UPS ... p-Rb at Ser780) were overexpressed, while cyclin-dependent kinase 4 (CDK4) and p-p53 at Ser392 were downregulated (Yin et al., 2012). The accumulation of P53 ...

Ubiquitination is a PTM characterized by the covalent binding of ubiquitin (Ub) molecule to a specific target protein. This essential PTM primarily determines protein stability by marking the target ...