The activity of a recombinant insulin receptor tyrosine kinase was measured using Raytide (Calbiochem, La Jolla, CA, USA) as substrate. The conditions for the in vitro kinase assays were as ...

Researchers investigate the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes.

Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according ...

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified in a chromosomal translocation associated with some anaplastic large cell lymphomas (ALCL), a subset of T-cell non ...

Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) acts as a negative regulator of the insulin signaling pathway by dephosphorylating both the insulin receptor (IR) and the insulin receptor ...

Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...

NDA accepted for review Zynquista (Lexicon Pharmaceuticals) Dual sodium-glucose co-transporter types 1 and 2 inhibitor As an adjunct to insulin ... penetant Bruton tyrosine kinase inhibitor ...