DOWN syndrome (DS), caused by trisomy of chromosome 21 (T21), affects approximately 1 in 700 live births. It is characterised by developmental delays, cognitive impairments, and increased ...

Quantification and characterization of these multiple HML-2 insertions in the human chromosome has been challenging due to their size, sequence homology with each other, and their repetitive nature.

Women are born with two X chromosomes and inherit one from each parent. But in every cell of their body, just one X chromosome is needed—so the other is randomly inactivated. Some cells use only ...

Get Instant Summarized Text (Gist) The completion of the final synthetic chromosome in the yeast genome marks a significant advancement in synthetic biology. This achievement enables the creation ...

Summary: New research shows that female mice expressing only a maternal X chromosome experience faster brain aging and cognitive decline compared to those expressing both maternal and paternal X ...

Down syndrome (Trisomy 21) is the most common chromosome abnormality in live births. Down syndrome accounts for the commonest form of intellectual disability caused by a known chromosome problem.

Laboratory of Biophysical Chemistry of Macromolecules, Institute of Chemical Sciences and Engineering (ISIC), School of Basic Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland; ...

Hyperactive interferon (IFN) signaling is a hallmark of Down syndrome (DS), a condition caused by trisomy 21 (T21); strategies that normalize IFN signaling could benefit this population.

1 Henan Provincial Institute of Medical Genetics, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, China 2 Department of Ultrasonography, Henan Provincial ...