The US Food and Drug Administration has approved vimseltinib (Romvimza, Deciphera Pharmaceuticals, LLC) to treat adult ...

This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...

Rheumatoid arthritis (RA) is an autoimmune disorder affecting millions worldwide, causing chronic inflammation, debilitating pain, and irreversible joint damage.

Results We found a subset of synovial Treg cells that recirculated into the bloodstream of patients with juvenile idiopathic and adult rheumatoid arthritis. These inflammation-associated (ia)Treg ...

Macrophages are the most abundant immune cells in the synovial membrane of OA and are involved in both maintaining and resolving the inflammatory process. Moreover, inflammatory infiltrates coexist ...

They can be found in both layers of this synovial membrane and contribute to normal joint function by producing extracellular matrix components and lubricants. However, under inflammatory conditions ...

hyperplasia of the synovial membrane is a hallmark of RA pathology, which is characterized by both hyperproliferation of synovial fibroblasts and massive infiltration of inflammatory immune cells, ...

which is mediated by mitochondrial membrane potential," the authors concluded. "With these findings, there’s potential to refine treatments for inflammatory conditions," O'Siorain said in the ...

MSK Doctors (03-300-010-048) is pleased to now be recommending Arthrosamid injections as a long-lasting knee osteoarthritis treatment.

It's characterized by runaway inflammation, usually sparked by an ... cells can act quickly and eject the section of their surface membrane with the gasdermin-D pore. The cell then zips the ...