When activated by semaphorin-3A (SEM3A), which is upregulated in MS lesions, the heterodimer inhibits two critical steps of remyelination: the differentiation of oligodendrocyte progenitor cells ...

Multiple sclerosis (MS) is an autoimmune disease ... Electron micrographs of the lumbar spinal cord showed remyelination in EAE-induced, Lingo1-knockout mice, but demyelination in wild-type ...

Moreover, the discovery of several compounds that can promote remyelination in animal models offers hope that function can be ...

A recent drug discovery could eventually help the visually impaired and those suffering from multiple sclerosis, traumatic stroke, and Alzheimer’s disease regain some of their vision and mental ...

MS was long considered a T-cell mediated disorder ... coupled with failed compensatory mechanisms like neuroplasticity and ...