rmdopen.bmj8d
Targeting the IL-17A pathway for therapy in early-stage tendinopathy
Objectives Tendinopathy is a frequent clinical problem and represents an extraordinary health economic and socioeconomic ...
eLife10d
ANKRD5: a key component of the axoneme required for sperm motility and male fertility
This valuable study reports on the critical role of ANKRD5 (ANKEF1) in sperm motility and male fertility. However, the supporting data remain incomplete. This work will be of interest to biomedical ...
Frontiers28d
Screening and Validation of Reference Genes for RT-qPCR Under Different Honey Bee Viral Infections and dsRNA Treatment
Table 2. Gene expression stability ranked by the geNorm, NormFinder, and BestKeeper algorithms. This study systematically analyzed 11 reference genes for RT-qPCR under viral infection in A. mellifera ...
Frontiers28d
Synthetic Artificial Long Non-coding RNA Shows Higher Efficiency in Specific Malignant Phenotype Inhibition Compared to the CRISPR/Cas Systems
Real-time Quantitative PCR (qPCR), dual-luciferase assay and relative phenotypic experiments were applied to severally test the expression of relative gene and therapeutic effects of our devices.
EurekAlert!7d
Researchers identify new p53 targets to combat cancer growth
A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled “Robust p53 phenotypes and ...
Nature4d
RNA amplification and cDNA synthesis for qRT-PCR directly from a single cell
Although qRT-PCR studies provide valuable information about the relative expression of transcripts in a cell, they are difficult to perform with very small numbers of cells (for example ...
eLife11d
Interplay of YEATS2 and GCDH mediates histone crotonylation and drives EMT in head and neck cancer
These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...
ahajournals.org11d
Fast Degradation of MecciRNAs by SUPV3L1/ELAC2 Provides a Novel Opportunity to Tackle Heart Failure With Exogenous MecciRNA
BACKGROUND: Circular RNAs derived from both nuclear and mitochondrial genomes are identified in animal cells.
technologynetworks24d
Considerations for qPCR Gene Expression Experiments in Cancer Research
Real-time PCR gene expression quantification is particularly useful in oncology research for biomarker discovery and monitoring therapeutic response, but eukaryotic gene expression is one of the most ...