The core components for small RNA biogenesis and effector functions have proliferated and specialized in eukaryotic lineages, resulting in diversified pathways that control expression of ...

UMD researchers have discovered key mechanisms in gene regulation that could improve the design of RNA-based medicines.

In another study in collaboration with the Narry Kim lab (Seoul National University), we demonstrated that 5’-phosphorylated end recognition by Dicer is important for precise and effective biogenesis ...

This target centers on RNA regulation, which ... new possibilities for drug discovery," Zhang said. "By targeting the pathways we've identified, we could develop treatments for diseases that ...

Trypanosomes are parasites that cause sleeping sickness, Chagas disease, and various animal diseases. Diagnosis and treatment remain complex and no effective vaccine has been developed. A better ...

Proteins that trigger cell senescence occupy much of the literature on aging, but a small RNA moves into the limelight ... noted that the authors used many different methods to validate the pathway ...

The biogenesis of miRNAs involves a multi-step process that begins in the nucleus and ends in the cytoplasm. Initially, miRNAs are transcribed by RNA polymerase II as long primary transcripts called ...

Importantly, ManS was produced by a noncanonical biogenesis mechanism: The ribonuclease RNase III, which usually cuts double-stranded RNA ... and secondary metabolic pathways, particularly ...

Importantly, ManS was produced by a noncanonical biogenesis mechanism: The ribonuclease RNase III, which usually cuts double-stranded RNA ... and secondary metabolic pathways, particularly ...