You have full access to this article via your institution. Figure 1: Reduced survival and increased tumor incidence in Pold1 D400A/D400A mice.
Biology lectures teach students that when a cell’s replication machinery comes together, DNA polymerase takes off down the double-helix like a car on a highway ...
A retrovirus with an RNA genome, which is copied into DNA by a reverse transcriptase, is prone to mutations because the enzyme lacks the 3’ to 5’ proofreading capability ... then amplifying the DNA ...
Exonuclease action of replicative polymerase gamma drives damage-induced mitochondrial DNA clearance
How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...
The high accuracy or fidelity of semi-conservative DNA replication is the product of nucleotide template interaction, polymerase-enhanced base selectivity, exonuclease proofreading and the post ...
which is the replicative DNA polymerase in the replisome, (prepared from a strain deleted of the genes for all the TLS polymerases and with the proofreading exonuclease fully active) itself could ...
Invitrogenâ„¢ Platinumâ„¢ SuperFi II DNA Polymerase is a hot-start, engineered proofreading DNA polymerase, providing superior fidelity and specificity to your PCR. With >300x Taq fidelity and buffer ...
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