In individuals with PNH, the RBCs become abnormally sensitive to the body’s immune system. This occurs due to a mutation in a gene called PIGA. Due to its rarity, the exact incidence is unknown ...

China has become the first country in the world to approve Roche’s anti-complement C5 antibody crovalimab, the only treatment for the rare disorder paroxysmal nocturnal haemoglobinuria (PNH ...

Regeneron will have a tough job taking on AstraZeneca’s big-selling Ultomiris in the market for paroxysmal nocturnal haemoglobinuria (PNH) therapies – but new biomarker data suggests it could ...

PNH can develop at any age ... on RBCs linked to PIGA gene mutation. Additional tests, such as coagulation studies and renal function tests, assess complications, while bone marrow biopsy and ...