which bind to the proteins target RELA (PDB ID: 6NV2) and p53 (PDB ID: 2OCJ). The Hexa, Fluo and Octa compounds' tests were negative for AMES toxicity, indicating that these compounds do not cause ...
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Background: Over-proliferation of mesangial cells (MCs) is one of the main pathological changes in the early stages of diabetic kidney disease (DKD). Roxadustat, an oral hypoxia-inducible factor (HIF) ...
However, the specific mechanisms by which DHIE regulates p53 in different subtypes of breast cancer and ... PLK4, and TYMS from the PDB database, and modified the protein by deleting ligands and water ...
Shah and colleagues take advantage of the presence of maternal and somatic ribosomes in zebrafish and confirm their differential expression during development. The authors convincingly show that ...
Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 402, Taiwan ...
They use genetics to knockout TEDC1 or TEDC2 in p53-negative RPE-1 cells and expansion microscopy to structurally characterize mutant centrioles. Biochemical methods and AlphaFold-multimer prediction ...
The scaffold protein JIP1 plays a key role in the c-Jun N-terminal kinase (JNK) signaling pathway by facilitating the colocalization of multiple kinases, thereby ensuring their precise and efficient ...
Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le Aldo Moro 5, Rome 00185, Italy ...
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