Nonribosomal peptides (NRPs) are a diverse class of natural ... This research not only clarifies the synthesis process but also opens avenues for re-engineering NRPSs to create new pharmaceutical ...

The article "Structures and mechanism of condensation in nonribosomal peptide synthesis," by Angelos Pistofidis, Pengchen Ma, Zihao Li, Kim Munro, Ken Houk, Martin Schmeing, and their collaborators at ...

The trend of using peptides as drug molecules has picked up momentum in the recent times owing to development in their synthesis and modification ... derived heavily disulfide bridged peptides) and ...

The Peptide Builder accommodates a wide range of synthesis scales, from 50 µmol to 1.0 mmol. It can be used with any kind of polymeric resin, including PS, PEGylated resins, and the standard ...

Short chains of amino acids can form drug delivery nanoparticles and boost the properties of potential medicines ...

"Although the α-D-ribofuranoside structure is frequently found in natural products, there have been fewer reports of the synthesis of α-D-ribofuranosides than of the β-anomers. Thus, the ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Researchers from the Institute of Science Tokyo and Osaka Medical and Pharmaceutical University said that they have developed a peptide that can bind to the spike proteins of SARS-CoV-2 to prevent ...

Table 1. Comparison of the specific enzymatic activity of the SPases for different synthetic peptides and a preprotein substrate (topmost). †Amino acids are abbreviated as single letter codes.

Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, 1-5 Yamadaoka, Suita 565-0871, Japan Department of Biotechnology, Osaka University ...