Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis ... We separated peripheral blood mononuclear cells (PBMC) by Ficoll-Paque density gradient.21 We cultured PBMC for 48 hours at a ...

Recent studies have highlighted the functional capacity of neutrophils as powerful mediators of tissue inflammation. Granule-packaged proteases and reactive oxygen intermediates, which are ...

N1 and N2 neutrophils or high density neutrophils (HDNs) and low density neutrophils (LDNs) have been used to distinguish neutrophils subpopulations with pro- vs. anti-tumor activity, respectively.

The role of polymorphonuclear neutrophils (PMNs) in biology is often recognized during pathogenesis associated with PMN hyper- or hypo-functionality in various disease states. However, in the vast ...

The manuscript addresses the 3D chromatin architecture in monocytes from patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the ...

Novel therapeutic targets and approaches are needed to improve outcomes. Neutrophils are the most abundant immune cell and among the first responders to infection. Appropriate neutrophil responses are ...

The impact of Card9 deletion on neutrophil function was assessed by an in vivo model of fungal infection and various functional assays, including endpoint dilution assay, apoptosis assay by flow ...

Neutrophils are major players in innate immune system. Here, we aimed to explore the heterogeneity and pro-tumour mechanisms of neutrophils in PDAC. Design We analysed single-cell transcriptomes of ...

Laboratory for Research on the Structure of Matter (LRSM), University of Pennsylvania, Philadelphia, United States ...

Density describes how closely packed the particles are in a solid, liquid or gas. There is little difference between the density of a liquid and its corresponding solid (eg water and ice). This is ...

Benefit: Higher yield, decrease cross talk. 4. Power/ground-connected fill Issue Addressed: Density gradients, Large IR drop, Layout becomes regular Benefit: Robustness to IR drop 5. Litho hotspot ...