eLife2d
Identification of a sub-population of synovial mesenchymal stem cells with enhanced treatment efficacy in a rat model of Osteoarthritis
This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...
thorax.bmj4d
Inflammation in preschool cystic fibrosis is of mixed phenotype, extends beyond the lung and is differentially modified by CFTR modulators
Background Early-life inflammation has long been recognised as a key pathophysiological process in the evolution of cystic ...
BMJ4d
Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2
M1 or M2-polarised macrophages in synovial tissues of patients with OA and OA mice were analysed by immunofluorescence and immunohistochemical staining. Mice with tuberous sclerosis complex 1 (TSC1) ...
BMJ1d
Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells
Cell viability was determined by trypan blue exclusion, and differential counts were evaluated by May–Grunwald and Giemsa staining. BAL cells were either cytocentrifuged on slides and 2% formaldehyde ...
Frontiers5d
The Two Faces of Tumor-Associated Macrophages and Their Clinical Significance in Colorectal Cancer
A variety of non-malignant stromal cells present at the complex tumor microenvironment are active players in cancer progression (1). Specifically in solid tumors, tumor associated macrophages (TAMs) ...