The Brigham and Women's Hospital Inc., Massachusetts General Hospital and UCL Business Ltd. have jointly patented new benzo[c][l,2,5]thiadiazolyl compounds and radiolabeled derivatives targeting ...
An MTF2-containing subcomplex of Polycomb Repressive Complex 2 promotes cell cycle progression through repression of D-type cyclin expression in certain cellular contexts.
PYX-201, an antibody-drug conjugate (ADC) with a microtubule inhibitor (optimized auristatin) payload that uniquely targets Extradomain-B Fibronectin (EDB+FN), a non-cellular structural component of ...
To investigate the role of epigenetic histone modifications on uric acid-induced priming that results in aggravated IL-1β, histone methyltransferase inhibitor, MTA (5′-deoxy-5′-methylthio-adenosine), ...
Interestingly, Smad-dependent TGFβ signaling activation enhances rudhira transcription, essential for microtubule stabilization during cardiovascular development. This dual regulation of TGFβ ...
Southern Medical University scientists have reported the discovery and preclinical characterization of novel microtubule-inhibiting agents being developed for the treatment of cancer. Discovery of ...
State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China Department of Medicinal Chemistry, School ...
ClusterTrack software allowed for the first time comprehensive measurements of microtubule behavior, including during stages of depolymerization, for which there is no known molecular marker ...
The main AEs were gastrointestinal or constitutional. Cumulative peripheral neuropathy (grades 1–3) resulting from microtubule inhibitor-specific toxicity, occurred in 20% of patients. At the q3w RP2D ...
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