This acts as a negative feedback loop by degrading dsDNA and other members of the pathway, such as cGAS or IRF3. Additionally, microautophagy is responsible for the final termination of STING ...

Antigen processing and presentation is the mechanism by which whole antigens are degraded and loaded onto MHC molecules for display on the cell surface for recognition by T cells. Both macrophages ...

Aging is the time-dependent process that all living organisms go through characterized by declining physiological function due to alterations in metabolic and molecular pathways. Many decades of ...

Objective Accumulation of mitochondria underlies T-cell dysfunction in systemic lupus erythematosus (SLE). Mitochondrial turnover involves endosomal traffic regulated by HRES-1/Rab4, a small GTPase ...

Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India ...