Alterations in the expression and activity of specific translation factors, and the uncoupling of translational regulation from inhibition by tumour cell stresses, such as hypoxia and nutrient ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

The second pathogenic mechanism involves a gain-of-function (GOF) due to the formation of toxic RNA foci from repeat expansion transcripts (reviewed by McEachin et al., 2020b). RNA foci are a ...

3 The Japan Agency for Medical Research and Development–Core Research for Evolutional Science and Technology (AMED–CREST), Japan Correspondence to Assistant Professor Satoshi Nojima, Department of ...