A team led by Prof. Wuran Wei from West China Hospital of Sichuan University and Dr. Dechao Feng from the Division of Surgery and Interventional Science at University College London has systematically ...

Previous research revealed that nuclear factor of activated T cells 1 (NFAT1) is a novel regulator of the mouse double minute 2 homolog (MDM2) oncogene, which acts by directly binding to the MDM2 P2 ...

The Purdue College of Veterinary Medicine picked a new associate dean for research, Dr. Susan Mendrysa, which became ...

A United States-based Nigerian doctoral researcher in systems biology and immunology, Prosper Chukwuemeka, is advancing cancer research by combining computational tools with biology.

However, loss of p53 tumour-suppressor activity can also occur through amplification of MDM2. As MDM2 is a negative regulator of p53, this promotes p53 degradation and inhibits p53 tumour ...

Learn more about whether Kymera Therapeutics, Inc. or Legend Biotech Corporation is a better investment based on AAII's A+ ...

Learn more about whether Kymera Therapeutics, Inc. or Sarepta Therapeutics, Inc. is a better investment based on AAII's A+ ...

has been awarded a research grant of ₹39.90 lakh for his proposed project “Preclinical evaluation of Hispolon and Varacin as natural product inhibitors of MDM2 as anti-cancer agents for oral ...

Meanwhile, a New Drug Application (NDA) for another one of Ascentage Pharma’s key drug candidates, the novel Bcl-2 selective inhibitor lisaftoclax (APG-2575), has already been accepted and granted the ...

Western blot assays were performed to identify the presence of p53, phospho-p53, and murine double minute 2 (MDM2) isoforms in plasma samples. Densitometric analysis was used to determine the ...