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IFN-γ release assays do not differentiate between active TB and latent TB infection. Host biosignatures comprised of cytokines should be investigated for a role in diagnostic algorithms.

Gene signatures identified a prominent response to interferon gamma (IFN-γ), as well as to tumour necrosis factor, interleukin-6 and hypoxia, in both humans and mice. Mass cytometry confirmed that ...

Background Interferon-γ release assays (IGRA) are a crucial diagnostic tool for the detection of a Mycobacterium tuberculosis infection in order to control and eliminate the tuberculosis (TB) epidemic ...

In the review, those with a positive tuberculin-skin-test (TST) or IFN gamma release assay (IGRA) result at baseline benefitted from greater protection by TPT (≥80%), regardless of age. However, the ...

Department of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China Department of Tuberculosis, Shenzhen Baoan People’s Hospital, The Second ...

With the addition of these two new assay launches, Zomedica has added 8 new assays in ... Except for statements of historical fact, this news release contains certain "forward-looking information" or ...

Current diagnosis of LTBI routinely relies on the detection and measurement of immune responses using the Tuberculin Skin Test (TST) and interferon gamma release assays (IGRAs). However, IGRA, which ...

Background: Interferon-gamma release assays (IGRA) are well-established immunodiagnostic tests for tuberculosis (TB) in adults. In children these tests are associated with higher rates of ...