Researchers from Osaka University found that knockdown of the Adaptor Protein Complex 2, Alpha 1 Subunit (AP2A1) rejuvenates ...

The activated PYK2/FAK-integrin complex recruits proteins including c-Src, and Grb2-Sos. The recruitment of Grb2-Sos leads to ERK activation via the sequential activation of Ras, Raf and MEK.

Janssen opted not to continue with the first two integrin targets at the end of 2021, due to "a lack of target validation in the specific disease of Janssen's interest," and has now dropped the ...