Purpose: The chemical interactions that cause drug incompatibility in solutions, with emphasis on the acid-base and ionized-nonionized forms of organic, weak, electrolyte drugs, are examined.

The driving concern for chemical storage is assuring the compatibility of chemicals if they should inadvertently mix. To avoid dangerous conditions, separate incompatible chemicals from each other.

In some instances where an incompatible chemical has been mistakenly introduced into the waste stream, a slow reaction takes place inside the bottle generating internal pressure. Whilst we make every ...

The chemical science behind this example is elaborated later. Another example of unexpected incompatibility is ketorolac tromethamine with several salts in which the organic drug is a cation (e.g ...