Repressed but ready to go: How bivalency holds developmental genes in a poised state for expression
As well as being essential in the precise packaging of DNA into the space of the nucleus, histone proteins are also the site ...
Science Daily2d
Uncovering how developmental genes are held in a poised state
New research has investigated the mechanism by which bivalency functions to poise genes for expression during cell differentiation, providing insight into a long-standing paradigm in the regulation of ...
eLife4d
Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab resistant HER2 positive breast cancer
This study presents a useful finding that targeting amino acid metabolism can overcome Trastuzumab resistance in HER2+ breast cancer. The evidence supporting the claims of the authors is solid and the ...
Nature6d
Epigenetics and MicroRNAs
A gene can only be transcribed if the chromatin structure changes temporarily to allow regulatory proteins to bind the relevant portion of the DNA. Histone tails—short arms that are separate ...
BBC6d
Exploring structure and form
Can include rhythm, melody, harmony, dynamics, texture, timbre and structure. of the music such as their melody close melodyDifferent pitched notes played one after another making a tune., ...
Frontiers6d
A Deep Insight Into Regulatory T Cell Metabolism in Renal Disease: Facts and Perspectives
Lipid nephrotoxicity could damage the structure and function of the glomerulus and tubules ... In lupus nephritis(LN), the researchers treated NZB/W lupus mice with a selective histone deacetylase 6 ...
Frontiers6d
Increasing Evidence That Irritable Bowel Syndrome and Functional Gastrointestinal Disorders Have a Microbial Pathogenesis
The human gastrointestinal tract harbors most of the microbial cells inhabiting the body, collectively known as the microbiota. These microbes have several implications for the maintenance of ...