Bone-marrow-derived stromal cells are the functional components of the haematopoietic stem cell (HSC) niche that support HSC homeostasis and they have anti-proliferative features that are in ...

The findings are published in the journal Cell Stem Cell. "We've shown that this decline in HSC function is not inevitable and appears to be reversible," said study senior and co-corresponding ...

The pre-HSCs (HSC progenitors) are stimulated by SCF derived from endothelium in the dorsal aorta, but not by TPO. After migrating to the fetal liver, pre-HSCs receive both SCF and TPO signals ...

[HSC] are clinically proved to be useful, so it really drives further research to better understand their regulation,” remarked Rong Lu, a stem cell biologist at the University of Southern California.

While other research groups had successfully added RAG1 to patient HSC, they were unable to properly regulate expression of the gene, and therefore couldn’t ensure that the stem cells were safe or ...

Fanconi anemia (FA) is a rare genetic disorder characterized by defective DNA repair, leading to hematopoietic stem cell (HSC) dysfunction and bone marrow failure. Replication stress, which ...

Featured data showcase the transformative potential of HSC gene therapy to enable cross-correction and restore enzymatic ...

Over the past 23 years, she has made innovative contributions in hematopoietic stem cell (HSC) biology, stem cell aging, epigenetic regulation of stem cells and the development of CRISPR tools for ...

We discovered that interferon gamma (IFNγ) promotes hematopoietic stem cell (HSC) division and myeloid differentiation in a mouse model of Mycobacterium avium infection (Nature 2010). Furthermore, ...