Hematopoietic stem cell gene therapy (HSC-GT) represents a cutting-edge treatment strategy for multiple genetic disorders. By ...

Bone-marrow-derived stromal cells are the functional components of the haematopoietic stem cell (HSC) niche that support HSC homeostasis and they have anti-proliferative features that are in ...

The findings are published in the journal Cell Stem Cell. "We've shown that this decline in HSC function is not inevitable and appears to be reversible," said study senior and co-corresponding ...

Fanconi anemia (FA) is a rare genetic disorder characterized by defective DNA repair, leading to hematopoietic stem cell (HSC) dysfunction and bone marrow failure. Replication stress, which ...

The pre-HSCs (HSC progenitors) are stimulated by SCF derived from endothelium in the dorsal aorta, but not by TPO. After migrating to the fetal liver, pre-HSCs receive both SCF and TPO signals ...

[HSC] are clinically proved to be useful, so it really drives further research to better understand their regulation,” remarked Rong Lu, a stem cell biologist at the University of Southern California.

report attempts to define a common stem-cell gene profile by comparing hematopoietic and neural stem-cells (Proc Natl Acad Sci USA 2001, 98:7934-7939). They isolated hematopoietic stem cells (HSC) ...

Featured data showcase the transformative potential of HSC gene therapy to enable cross-correction and restore enzymatic ...

To ensure continuous blood cell production is necessary to preserve hematopoietic stem cells (HSC) in a resting state while preserving their capacity to differentiate on demand into different blood ...