eLife1d
Bridging the Gap in Cancer Cell Behavior Against Matrix Stiffening: Insights from a Trizonal Model
Laboratory for Research on the Structure of Matter (LRSM), University of Pennsylvania, Philadelphia, United States ...
eLife3d
Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche
Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...
ahajournals.org14d
Abstract WP362: Can Plasma Extracellular Vesicle-Associated Proteins Differentiate Cerebrovascular Disease Pathologies?
Activated ECs upregulate and cleave many junctional proteins, including soluble vascular cell adhesion ... are due to lack of biomarkers to differentiate pathologies. Utilizing extracellular vesicles ...
C&EN19d
Engineered Extracellular Vesicles Modified by Angiopep-2 Peptide Promote Targeted Repair of Spinal Cord Injury and Brain Inflammation
Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Engineered extracellular vesicles play an increasingly important role in the treatment ...
verywellhealth21d
Pleura Anatomy, Function, and Conditions That Affect It
The pleura (plural: pleurae) is a two-layered membrane that covers the lung. Between the layers is a small amount of lubricating fluid, known as pleural fluid, which helps cushion the lung and reduce ...
The EMBO Journal27d
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease
Disorders of surfactant protein biology cause dysfunction of alveolar type 2 cells and can lead to interstitial lung disease. This study describes the development of genetically manipulable, mature ...
Science Daily27d
The proteins that make cell-to-cell cargo transport possible
These particles, called extracellular ... an ion channel -- a protein that opens a corridor allowing electrical charges to pass through the protective outer membrane, a necessary step to keep ...
ahajournals.org28d
ECM Modifications Driven by Age and Metabolic Stress Directly Promote the Vascular Smooth Muscle Cell Osteogenic Processes
The ECM (extracellular ... including ECM and basement membrane organization, biomineral tissue development (involving COL1A1 [collagen type 1-α1], COL1A2 [collagen type 1-α2], LOXL1, and ECM1 [ECM ...
Frontiers28d
Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases
Extracellular vesicles (EVs) are released by cells and transport their contents (micro RNAs, mRNA, proteins, and long noncoding RNAs) to nearby or distant cells for cell-to-cell communication.
Phys.org29d
Extracellular vesicles contain ion channels that make cell-to-cell cargo transport possible
These particles, called extracellular ... contain an ion channel—a protein that opens a corridor allowing electrical charges to pass through the protective outer membrane, a necessary step ...