receptor trafficking in the endosome, DNA damage responses and inflammatory pathways. Moreover, we describe defects in ubiquitin–UBD interactions that are relevant for the development of ...

This extension builds on a 2024 agreement to define and discover biomarkers within the DNA damage response (DDR) biological space to predict the clinical benefit of one or more drugs in Debiopharm ...

Since Los Angeles’ unprecedented January firestorms, the Eaton and Palisades fires have consumed nearly 40,000 acres of homes, businesses and landmarks in Altadena and Pacific Palisades and have ...

Hope is not passive wishing but an active, dynamic process. According to Hope Theory, hope involves two components: agency and pathways. Agency is the belief in one’s capability to act ...

The Los Angeles wildfires of 2025 have left incredible devastation in their wakes. Although official damage assessments are still ongoing, the California Department of Forestry and Fire Protection ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means ...

The endosomal pathway is essential for regulating cell signaling ... by endosomal sorting complex required for transport (ESCRT) proteins. During endosome maturation Rab5 is replaced by Rab7 on ...

A Norwegian ship suspected of being involved in "serious damage" to an underwater telecoms cable between Latvia and Sweden has been boarded by police. The Silver Dania cargo vessel, with an all ...