Mild (CrCl 60-89 mL/min) or moderate (CrCl 30-59 mL/min) renal impairment: reduce the Effexor XR total daily dose by 25% to 50%. Severe renal impairment (CrCl <30 mL/min) or patients undergoing ...

Your healthcare provider may recommend gradual dose increases if needed. Effexor XR Starting dose: 75 mg daily, although some people will start at 37.5 mg daily for the first week before ...